Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. | Zendy

Yoshihisa Kitamura | Zendy; Toshio Kaneda | Zendy; Yasuyuki Nomura | Zendy

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Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist.

Author(s) -

Yoshihisa Kitamura,

Toshio Kaneda,

Yasuyuki Nomura

Publication year - 1991

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.55.177

Subject(s) - muscarinic acetylcholine receptor , muscarinic agonist , nootropic , agonist , pharmacology , chemistry , neuroscience , computer science , medicine , psychology , receptor , biochemistry

We here investigated the effects of nebracetam (WEB 1881 FU 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate), a novel pyrrolidinone nootropic, on the rise of intracellular Ca2+ concentration ([Ca2+]i) in Jurkat cells, a human leukemic T cell line. Nebracetam induced a rise of [Ca2+]i in the medium with 1 mM Ca2+ and without Ca2+ (plus 1 mM EGTA). The nebracetam-induced [Ca2+]i rise was blocked by atropine greater than pirenzepine greater than AF-DX 116. From these results, nebracetam seems to act as an agonist for human M1-muscarinic receptors.

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