Open AccessEffects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist.
Author(s) -
Yoshihisa Kitamura,
Toshio Kaneda,
Yasuyuki Nomura
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.55.177
Subject(s) - muscarinic acetylcholine receptor , muscarinic agonist , nootropic , agonist , pharmacology , chemistry , neuroscience , computer science , medicine , psychology , receptor , biochemistry
We here investigated the effects of nebracetam (WEB 1881 FU 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate), a novel pyrrolidinone nootropic, on the rise of intracellular Ca2+ concentration ([Ca2+]i) in Jurkat cells, a human leukemic T cell line. Nebracetam induced a rise of [Ca2+]i in the medium with 1 mM Ca2+ and without Ca2+ (plus 1 mM EGTA). The nebracetam-induced [Ca2+]i rise was blocked by atropine greater than pirenzepine greater than AF-DX 116. From these results, nebracetam seems to act as an agonist for human M1-muscarinic receptors.