Open AccessForskolin preferentially dilates the afferent arteriole in the canine kidney.
Author(s) -
Toshiaki Takahashi,
Kouichi Hasui,
Tetsuo Shoji,
Yasuharu Aki,
Hideyasu Kiyomoto,
Hiroshi Itoh,
Youichi Abe
Publication year - 1991
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.55.161
Subject(s) - forskolin , afferent arterioles , arteriole , medicine , endocrinology , renal function , renal blood flow , kidney , urinary system , chemistry , afferent , blood pressure , heart rate , circulatory system , renin–angiotensin system , receptor
Intrarenal infusion of forskolin (0.2 microgram/kg/min) in anesthetized dogs increased renal blood flow (RBF) and glomerular filtration rate (GFR) to the same degree but did not change the mean arterial pressure or heart rate. Forskolin also increased urine flow and urinary sodium excretion. The proportional increases in RBF and GFR may result from a preferential action of forskolin to dilate the afferent arteriole.