Open AccessEffect of L-Cysteine on Distribution Volume of 1-(Tetrahydro-2-Furanyl)-5-Fluorouracil
Author(s) -
Nobuo Kawabata,
Ken’ichi Yano,
Hiromitsu Ohno,
Tomoki Nakashima
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.487
Subject(s) - chemistry , volume of distribution , fluorouracil , plasma volume , cysteine , distribution (mathematics) , volume (thermodynamics) , distribution volume , endocrinology , medicine , biochemistry , pharmacokinetics , chemotherapy , mathematics , thermodynamics , physics , mathematical analysis , enzyme
Higher plasma concentrations of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) were obtained after administration of FT (100 mg/kg, i.v.) combined with L-cysteine (CySH, 500 mg/kg, p.o.). The volume of distribution (Vd) and body fluid volumes significantly decreased. These results suggest that the increase of the plasma concentrations of FT can be attributed to the decrease of the Vd of FT, which is considered to be based on the decrease of body fluid volumes by the combined administration of CySH.