Open AccessDopamine Receptor Subtypes That Induce Hyperactive Urinary Bladder Response in Anesthetized Rats
Author(s) -
Hitoshi Kontani,
Tsutomu Inoue,
Takeshi Sakai
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.482
Subject(s) - sulpiride , bromocriptine , dopamine receptor , chemistry , stimulation , sch 23390 , endocrinology , haloperidol , medicine , dopamine , agonist , receptor , urinary bladder , lisuride , pharmacology , dopaminergic , dopamine agonist , prolactin , hormone
In anesthetized rats, SKF 38393 (10 mg/kg, i.v.) did not facilitate urinary bladder motility, but bromocriptine (BR, 5 mg/kg, i.v.) alone and the combination of BR (1 mg/kg, i.v.) and SKF 38393 (1 mg/kg, i.v.) induced a hyperactive bladder response (HBR). Both HBR induced by BR alone or BR and SKF 38393 combined was suppressed by SCH 23390, sulpiride or haloperidol. These results indicate that HBR is mediated by the activation of D-2 receptors, and the effects of D-2 agonists on bladder motility are potentiated by the simultaneous stimulation of D-1 receptors.