Binding Profile of SM-9018, a Novel Antipsychotic Candidate | Zendy

Terufumi Kato | Zendy; Akira Hirose | Zendy; Yukihiro Ohno | Zendy; Hiroshi Shimizu | Zendy; Hiroyasu Tanaka | Zendy; Mitsutaka Nakamura | Zendy

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Binding Profile of SM-9018, a Novel Antipsychotic Candidate

Author(s) -

Terufumi Kato,

Akira Hirose,

Yukihiro Ohno,

Hiroshi Shimizu,

Hiroyasu Tanaka,

Mitsutaka Nakamura

Publication year - 1990

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.54.478

Subject(s) - receptor , gabaa receptor , opiate receptors , binding site , phencyclidine , chemistry , antipsychotic , biochemistry , antagonist , nmda receptor , medicine , schizophrenia (object oriented programming) , psychiatry , (+) naloxone

The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9 nM, respectively), and it had moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively). However, SM-9018 had only negligible affinity for alpha 2, opiate, glutamate, phencyclidine, benzodiazepine and GABAA receptors. These results suggest that SM-9018 may be a novel antipsychotic agent with binding affinity for 5-HT2 and 5-HT1A receptors.

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