Open AccessEffects of Thiamine Administration on Hypothermia and Hypothalamic Histamine Levels in Dietary-Induced Thiamine Deficient Rats
Author(s) -
Kenji Onodera,
Hisashi Satoh,
Takehiko Watanabe
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.339
Subject(s) - thiamine , histamine , endocrinology , medicine , hypothermia , thiamine deficiency , hypothalamus , chemistry
The rats maintained on a thiamine-deficient diet for 30 days showed hypothermia, and their histamine levels increased significantly in both the anterior and posterior hypothalamus. When these rats were administered, thiamine disulfide and/or provided with thiamine-added diet for a further 30 days, the rats recovered from hypothermia, and histamine levels were decreased to the normal level. Thus, it is probable that the increased histamine levels in the hypothalamus, especially those in its anterior region, are closely related to the hypothermia in thiamine-deficient rats.