Open AccessEffects of Ceruletide, Administered Singly and in Combination with Central-Acting Drugs, on Discrete Shuttle Avoidance Response in Mice
Author(s) -
Hisashi Kuribara,
Takayasu Asami,
Iturou Ida,
Sakutaro Tadokoro
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.325
Subject(s) - chlorpromazine , haloperidol , ceruletide , avoidance response , pharmacology , pilocarpine , perphenazine , chemistry , methamphetamine , anesthesia , medicine , endocrinology , dopamine , epilepsy , cholecystokinin , receptor , psychiatry
The single administration of ceruletide at 10-300 micrograms/kg, i.p., slightly but significantly decreased the response rate (frequency of shuttles) under a discrete avoidance task in mice. Over 10 micrograms/kg of ceruletide attenuated the increase in the response rate induced by methamphetamine (0.5 mg/kg, s.c.). However, ceruletide, at 1-300 micrograms/kg, did not significantly enhance the response- and/or avoidance-decreasing effects of chlorpromazine (1 mg/kg, s.c.), haloperidol (0.1 mg/kg, s.c.), pilocarpine (4 mg/kg, s.c.) and N6-(L-2-phenylisopropyl)-adenosine (0.1 mg/kg, s.c.), but rather tended to reduce the avoidance-decreasing effect of chlorpromazine and pilocarpine at 1-100 micrograms/kg.