Open AccessCooperation of ATP and Norepinephrine in Inducing Contractile Responses in Guinea Pig Vas Deferens
Author(s) -
Isao Kishi,
Fumiaki Hata,
Tadayoshi Takeuchi,
Toshiaki Ishii,
Osamu Yagasaki
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.253
Subject(s) - vas deferens , guinea pig , norepinephrine , chemistry , medicine , endocrinology , pharmacology , biology , dopamine
Stimulation of the hypogastric nerve to the guinea pig vas deferens induced biphasic contraction consisting of a rapid transient phase (mediated by ATP) and a delayed tonic phase (mediated by norepinephrine, NE), whereas stimulations in the presence of selective antagonists caused each contractile phase separately. Stimulation in the absence of antagonist induced a larger rapid transient contraction than that induced by stimulation in the presence of alpha 1-antagonist. Results obtained in separate or simultaneous additions of exogenous ATP and NE showed synergism in the rapid transient contraction. These findings indicate that NE assisted ATP in inducing the hypogastric nerve-mediated contractile response in guinea pig vas deferens, but not vice versa.