Open AccessEffects of Nitroglycerin on Stable Thromboxane A2 Analogue-Induced, Nifedipine-Resistant Contraction in Canine Basilar Artery
Author(s) -
Hachiro Usui,
Yoshinobu Akimoto,
Kazuyoshi Kurahashi,
Hiroaki Shirahase,
Motohatsu Fujiwara,
Shoji Shibata,
Aritomo Suzuki
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.54.237
Subject(s) - nifedipine , basilar artery , contraction (grammar) , thromboxane a2 , artery , medicine , muscle contraction , egta , cardiology , chemistry , anesthesia , calcium , platelet
The stable thromboxane A2 analogue, STA2, caused concentration-dependent contractions in the canine basilar artery. In Ca2(+)-free medium containing EGTA (0.1 mM) and nifedipine (10(-6) M), the addition of Ca2+ (2.5 mM) in the presence of STA2 (10(-8) M) caused a tonic contraction (nifedipine-resistant Ca2(+)-induced contraction). In the basilar artery, nitroglycerin did not significantly affect such nifedipine-resistant Ca2(+)-induced contractions, but nearly abolished the contraction in the coronary artery. The present experiments suggest that the regulatory mechanism of mobilized Ca2+ for the nifedipine-resistant Ca2(+)-induced contraction produced by STA2 in the basilar artery is different from that in the coronary artery.