Inhibitory Modulation on the Reflex Tracheal Constriction Induced by Afferent Vagal Stimulation | Zendy

Miwa Misawa | Zendy; Yoshinori TAKAHASHI | Zendy; Junzo Kamei | Zendy; Tomokazu HOSOKAWA | Zendy; Saizo YANAURA | Zendy

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Inhibitory Modulation on the Reflex Tracheal Constriction Induced by Afferent Vagal Stimulation

Author(s) -

Miwa Misawa,

Yoshinori TAKAHASHI,

Junzo Kamei,

Tomokazu HOSOKAWA,

Saizo YANAURA

Publication year - 1990

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.53.506

Subject(s) - reflex , constriction , vagovagal reflex , stimulation , hexamethonium , atropine , oculocardiac reflex , bronchoconstriction , propranolol , medicine , anesthesia , inhibitory postsynaptic potential , airway

Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine, a reflex dilatation following a constriction was observed by afferent vagal stimulation. The reflex dilatation was inhibited about 50% by propranolol and was abolished by hexamethonium. These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition.

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