Open AccessInhibitory Modulation on the Reflex Tracheal Constriction Induced by Afferent Vagal Stimulation
Author(s) -
Miwa Misawa,
Yūzō Takahashi,
Junzo Kamei,
Tomokazu Hosokawa,
Saiζo Yanaura
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.506
Subject(s) - reflex , constriction , vagovagal reflex , stimulation , hexamethonium , atropine , oculocardiac reflex , bronchoconstriction , propranolol , medicine , anesthesia , inhibitory postsynaptic potential , airway
Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine, a reflex dilatation following a constriction was observed by afferent vagal stimulation. The reflex dilatation was inhibited about 50% by propranolol and was abolished by hexamethonium. These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition.