Open AccessStimulation of Oxygen Consumption of Platelets by Solcoseryl and Cardiocrome during In Vitro Aging for 5 Days
Author(s) -
Tetsuo Shimizu
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.499
Subject(s) - stimulation , platelet , in vitro , oxygen , chemistry , consumption (sociology) , microbiology and biotechnology , pharmacology , medicine , biology , biochemistry , art , aesthetics , organic chemistry
Solcoseryl (SOL) and Cardiocrome (CAR) produced decreases in the partial oxygen pressure of platelet suspensions, indicating the acceleration of platelet oxygen consumption. However, the peak response to CAR was much faster than that to SOL. Application of 1 ml of SOL to 20 ml of platelet suspension stored for 1 day produced increases of 1 nmol ATP per min per 10(9) platelets. The same increases in oxygen consumption appeared after 3 or 5 day-storage.