Open AccessEffects of Intracerebroventricular Administration of Magnesium Sulphate on Blood Pressure and Heart Rate in Anesthetized Normotensive and Hypertensive Rats
Author(s) -
Francesco Squadrito,
Anna L. Buemi,
R. Sturniolo,
Michele Buemi,
Francesco Corica,
N Frisina,
G Squadrito,
Achille P. Caputi
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.495
Subject(s) - blood pressure , magnesium , heart rate , medicine , endocrinology , anesthesia , chemistry , organic chemistry
Intracerebroventricular (i.c.v.) injection of magnesium sulphate (MgSO4:2.5, 5 and 10 mumol in 5 microliters) decreased blood pressure and heart rate in both anesthetized normotensive (WKY) and hypertensive rats (SHR). The effects were greater in WKY than in SHR. Moreover, a pretreatment with hexamethonium (2 mg/kg, i.v.) significantly blunted the hypotensive and bradycardic effects induced by i.c.v. injection of 10 mumol of MgSO4 in both WKY and SHR. Our data suggest that MgSO4 produces hypotensive and bradycardic effects when injected i.c.v. in both WKY and SHR.