Open AccessEffects of Methamphetamine on Regional Cerebral Glucose Utilization in Rats with Unilateral Lesion of Substantia Nigra
Author(s) -
Yutaka Gomita,
Yasuyuki Ichimaru,
Katsushi Furuno,
Yasunori Araki
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.414
Subject(s) - substantia nigra , methamphetamine , lesion , cerebral cortex , caudate nucleus , medicine , endocrinology , putamen , chemistry , anesthesia , neuroscience , psychology , surgery , dopamine , dopaminergic
In rats with electrocoagulation of the unilateral substantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats.