Open AccessRole of Nitric Oxide in Non-Adrenergic, Non-Cholinergic Nerve-Mediated Relaxation in Dog Duodenal Longitudinal Muscle Strips
Author(s) -
Noboru Toda,
Hiroshi Baba,
Tomio Okamura
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.281
Subject(s) - phentolamine , nitric oxide , tetrodotoxin , cholinergic , medicine , endocrinology , atropine , adrenergic , propranolol , stimulation , chemistry , arginine , acetylcholine , biochemistry , amino acid , receptor
Transmural electrical stimulation caused a relaxation in the dog duodenal longitudinal muscle strips treated with atropine, phentolamine and propranolol, which was abolished by tetrodotoxin. The relaxation was suppressed by oxyhemoglobin and L-NG-nitro-arginine (L-NA), but not influenced by D-NA. Inhibition by L-NA was reversed by L-arginine, but not by D-arginine. The response to transmural electrical stimulation was similar to that caused by nitric oxide or nitroglycerin. Nitric oxide appears to participate importantly in non-adrenergic, non-cholinergic nerve-mediated relaxation.