Role of Nitric Oxide in Non-Adrenergic, Non-Cholinergic Nerve-Mediated Relaxation in Dog Duodenal Longitudinal Muscle Strips | Zendy

Noboru Toda | Zendy; Hiroshi Baba | Zendy; Tomio Okamura | Zendy

Open Access

Role of Nitric Oxide in Non-Adrenergic, Non-Cholinergic Nerve-Mediated Relaxation in Dog Duodenal Longitudinal Muscle Strips

Author(s) -

Noboru Toda,

Hiroshi Baba,

Tomio Okamura

Publication year - 1990

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.53.281

Subject(s) - phentolamine , nitric oxide , tetrodotoxin , cholinergic , medicine , endocrinology , atropine , adrenergic , propranolol , stimulation , chemistry , arginine , acetylcholine , biochemistry , amino acid , receptor

Transmural electrical stimulation caused a relaxation in the dog duodenal longitudinal muscle strips treated with atropine, phentolamine and propranolol, which was abolished by tetrodotoxin. The relaxation was suppressed by oxyhemoglobin and L-NG-nitro-arginine (L-NA), but not influenced by D-NA. Inhibition by L-NA was reversed by L-arginine, but not by D-arginine. The response to transmural electrical stimulation was similar to that caused by nitric oxide or nitroglycerin. Nitric oxide appears to participate importantly in non-adrenergic, non-cholinergic nerve-mediated relaxation.

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