Open AccessDirect Evidence Indicating That a GABA-Mimetic Stimulates Acid Secretion through Central Mechanisms
Author(s) -
Nobuyuki Hara,
Youichi Hara,
Yasuhiro Natsume,
Yoshiaki Gotō
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.271
Subject(s) - baclofen , secretagogue , secretion , chemistry , endocrinology , hypothalamus , medicine , aminobutyric acid , basal (medicine) , central nervous system , pharmacology , biology , biochemistry , agonist , receptor , insulin
Acid secretagogue effects of central and peripheral baclofen were compared in the rat. Intravenously (0.1-1.0 mg/kg) and intracerebroventricularly (0.1-1.0 micrograms) administered baclofen augmented acid output to the same degree in a dose-dependent manner. GABA microinjected into the lateral hypothalamus (200 and 400 micrograms) significantly increased acid output. These support the proposal that baclofen stimulates acid secretion through central mechanisms and also the possible role of GABA in central regulation mechanisms of acid secretion.