Open AccessDominant Vasodilator Action of Norepinephrine in Isolated, Non-Preconstricted Simian Facial Veins
Author(s) -
Shigetoshi Chiba,
Miyoko Tsukada
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.267
Subject(s) - vasodilation , phenylephrine , vasoconstriction , isoprenaline , norepinephrine , propranolol , cannula , medicine , anesthesia , cardiology , blood pressure , stimulation , surgery , dopamine
Using the cannula inserting method, we investigated the vascular responses to norepinephrine (NE), phenylephrine and isoprenaline (Isp) in isolated, perfused simian facial veins. NE usually induced only a vasodilation in non-preconstricted veins. Phenylephrine consistently induced only a slight vasoconstriction, and Isp produced only a vasodilation. NE-induced vasodilations were reversed to vasoconstrictions after treatment with a relatively larger dose of propranolol. It is concluded that simian facial veins have a spontaneous intrinsic tone and dominant abundant beta-adrenoceptors but sparse alpha 1-adrenoceptors.