Open AccessAntihypertensive Effect of CS-905, a Novel Dihydropyridine Calcium Blocker, in Conscious Hypertensive Dogs
Author(s) -
Kiyoshi Oizumi,
Masaaki Miyamoto,
Hiroyuki Koike
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.53.264
Subject(s) - nicardipine , dihydropyridine , diltiazem , blood pressure , plasma renin activity , heart rate , medicine , pharmacology , calcium , nisoldipine , tachycardia , endocrinology , chemistry , renin–angiotensin system , nifedipine
CS-905, (+-)-3-(1-diphenylmethylazetidin-3-yl)5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridine-dicarboxy lat e, is a novel dihydropyridine calcium blocker. Both CS-905 and nicardipine, when administered orally, produced a dose-dependent fall of blood pressure in conscious perinephritic hypertensive dogs. Unlike the hypotensive effect of nicardipine, that of CS-905 has a gradual onset and is long-lasting, with little increase in the heart rate and plasma renin activity (PRA). The lack of both tachycardia and increase of PRA is probably mostly due to the slow onset of antihypertensive action following CS-905.