The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice. | Zendy

Masaaki Ishikawa | Zendy; Yoshio Takayanagi | Zendy; Kenichi Sasaki | Zendy

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The deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice.

Author(s) -

Masaaki Ishikawa,

Yoshio Takayanagi,

Kenichi Sasaki

Publication year - 1990

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.52.652

Subject(s) - buthionine sulfoximine , nephrotoxicity , glutathione , cisplatin , pharmacology , toxicity , chemistry , chemotherapy , biochemistry , medicine , enzyme , organic chemistry

Pretreatment of buthionine sulfoximine (500 mg/kg, i.p., BSO), a potent glutathione-depleting agent, markedly increased the lethality and nephrotoxicity of cisplatin. These results suggest that a reactive electrophilic intermediate may be involved in the mechanism of cisplatin nephrotoxicity and moreover, that renal glutathione may play a protective role against cisplatin-induced nephrotoxicity.

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