Open AccessThe deleterious effect of buthionine sulfoximine, a glutathione-depleting agent, on the cisplatin toxicity in mice.
Author(s) -
Masaaki Ishikawa,
Yoshio Takayanagi,
Kenichi Sasaki
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.52.652
Subject(s) - buthionine sulfoximine , nephrotoxicity , glutathione , cisplatin , pharmacology , toxicity , chemistry , chemotherapy , biochemistry , medicine , enzyme , organic chemistry
Pretreatment of buthionine sulfoximine (500 mg/kg, i.p., BSO), a potent glutathione-depleting agent, markedly increased the lethality and nephrotoxicity of cisplatin. These results suggest that a reactive electrophilic intermediate may be involved in the mechanism of cisplatin nephrotoxicity and moreover, that renal glutathione may play a protective role against cisplatin-induced nephrotoxicity.