Open AccessCarteolol is a useful tool to prove the tonically functioning nature of presynaptic .BETA.-adrenoceptors on peripheral noradrenergic neurons but not on central catecholaminergic neurons.
Author(s) -
Kaoru Ohno,
Shinichi Nakamura,
Yoshio Goshima,
Yoshimi Misu
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.52.643
Subject(s) - catecholaminergic , facilitation , brainstem , chemistry , catecholaminergic cell groups , norepinephrine , medicine , adrenergic receptor , endocrinology , neuroscience , catecholamine , dopamine , biology , receptor , biochemistry
Effects of carteolol on norepinephrine (NE) release were studied at 2 Hz mainly in rat hypothalamic slices. Isoproterenol at 1 and 10 nM concentration-dependently facilitated NE release. Isoproterenol (10 nM)-induced facilitation was antagonized by 1 and 10 nM dl-carteolol, but not antagonized by 1 nM d-carteolol. dl-Carteolol alone at 1 nM to 10 microM did not inhibit NE release. In brainstem slices, 10 nM isoproterenol also facilitated NE release, and this facilitation tended to be antagonized by 1 nM dl-carteolol. Nanomolar concentrations of carteolol stereoselectively antagonized isoproterenol-induced facilitation of NE release via presynaptic beta-adrenoceptors in rat hypothalamic slices.