Open AccessAssessment of vascular permeability increase in the mouse by dye leakage during paw edema.
Author(s) -
Xiao Fei Qu,
Masahiko Hayashi,
Kohji Yamaki,
Sachiko Ohishi
Publication year - 1990
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.52.500
Subject(s) - histamine , autacoid , vascular permeability , chemistry , bradykinin , evans blue , platelet activating factor , pharmacology , permeability (electromagnetism) , edema , endocrinology , medicine , biochemistry , receptor , membrane
Vascular permeability increase induced by histamine, bradykinin, platelet-activating factor (PAF), or phorbol myristate acetate (PMA) in the mouse paw was assessed by the dye leakage method. The amount of dye extracted from the paw showed a clear dose-response relationship to the dose of each agonist injected into the paw. Among the autacoids used, PAF showed the most potent activity in the mouse paw. The results are consistent with those seen in the rat dorsal skin as previously reported. Involvement of histamine, 5-hydroxytryptamine and PAF is suggested in the vascular permeability increase induced by PMA in the mouse paw.