Open AccessThe evidence for the involvement of the 5-HT1A receptor in 5-HT syndrome induced in mice by tryptamine.
Author(s) -
Jun Yamada,
Yukihiko Sugimoto,
Kazuyoshi Horisaka
Publication year - 1989
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.51.421
Subject(s) - methysergide , ketanserin , tryptamine , hindlimb , 5 ht receptor , endocrinology , medicine , receptor , chemistry , serotonin , spiperone , pharmacology
The involvement of the 5-HT1A receptor in the 5-HT syndrome (head weaving and hindlimb abduction) induced in DBA mice by tryptamine was investigated. Methysergide, (-)propranolol and spiperone suppressed both the head weaving and hindlimb abduction induced by tryptamine. However, ketanserin and ICS 205-930 did not affect them. Haloperidol induced small decreases in the head weaving, but had no effect on the hindlimb abduction. These results indicate that the 5-HT syndrome induced by tryptamine in mice is mediated by the 5-HT1A receptor. Therefore, 5-HT syndrome may also be associated with the 5-HT1A receptor in mice, as it is in rats.