Influence of Bay K 8644 on aequorin-loaded human platelets. | Zendy

Nobuyuki Ogawa | Zendy; Hiroshi Ono | Zendy

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Influence of Bay K 8644 on aequorin-loaded human platelets.

Author(s) -

Nobuyuki Ogawa,

Hiroshi Ono

Publication year - 1989

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.51.306

Subject(s) - aequorin , platelet , thrombin , cytoplasm , chemistry , biophysics , bay , platelet aggregation , calcium , biochemistry , medicine , biology , civil engineering , engineering , organic chemistry

In aequorin-loaded human platelets, Bay k 8644 (1-100 microM) had no effect on the resting level of cytoplasmic Ca2+ and did not induce aggregation by itself. Though the rise of cytoplasmic Ca2+ and platelet aggregation induced by thrombin (0.1 U/ml) also was not inhibited by 1-10 microM of Bay k 8644, at concentration of 3-10 microM, it dose-dependently reduced those induced by collagen (5 micrograms/ml). The present study shows that human platelets do not have dihydropyridine sensitive Ca channels.

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