Open AccessDistribution of substance P and methionine-enkephalin in salivary glands and effect of chronic morphine treatment on levels of these peptides.
Author(s) -
Norifumi Yonehara,
Huei-Yann Tsai,
Jiqiang Chen,
Reizo Inoki
Publication year - 1989
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.50.503
Subject(s) - substance p , endocrinology , medicine , submandibular gland , salivary gland , radioimmunoassay , neuropeptide , morphine , sublingual gland , enkephalin , methionine , chemistry , saliva , opioid , receptor , amino acid , biochemistry
Substance P-like immunoreactivity (SPLI) and methionine-enkephalin-like immunoreactivity (MELI) were determined in salivary glands from rats by radioimmunoassay. In all salivary glands investigated (submandibular gland, sublingual gland and parotid gland), SPLI and MELI were detected. The amount of both peptides is comparable to or relatively higher than those found in any other peripheral tissue. The level of SPLI showed a tendency to increase following chronic treatment with morphine: the enhancement in the submandibular gland and the sublingual gland was especially remarkable. The level of MELI was decreased, particularly in the submandibular gland.