Open AccessEffects of opioid peptides administered in conscious rats on the changes in blood adrenaline leves caused by immobilization stress.
Author(s) -
Mikio Nakamura,
Kunie Kamata,
Hakubun Inoue,
Masaaki Inaba
Publication year - 1989
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.50.354
Subject(s) - opioid , opioid peptide , pharmacology , medicine , anesthesia , chemistry , receptor
Effects of several opioid peptides administered in the lateral cerebroventricle on the changes in blood adrenaline (AD) levels were examined at 10, 20 and 30 min after the start of immobilization in conscious rats. beta-Endorphin, (D-Ala2)-Met-enkephalinamide, morphiceptin and (D-Ala2, D-Leu5)-enkephalinamide produced significantly lower elevations of AD than the control, and the effect was enhanced by naloxone. The effect of dynorphin, however, was almost the same as that of the control.