Use of cultured renal epithelial cells for the study of cisplatin toxicity. | Zendy

Nobuyuki Fukuishi | Zendy; Munekazu Gemba | Zendy

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Use of cultured renal epithelial cells for the study of cisplatin toxicity.

Author(s) -

Nobuyuki Fukuishi,

Munekazu Gemba

Publication year - 1989

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.50.247

Subject(s) - nephrotoxicity , cisplatin , toxicity , in vitro , cell culture , kidney , chemistry , pharmacology , enzyme , drug , biochemistry , biology , medicine , chemotherapy , endocrinology , organic chemistry , genetics

The nephrotoxicity of cisplatin was evaluated in an in vitro system with an established cell line of normal rat kidney, NRK-52E. Leakage of enzymes from the cells into the culture medium increased when they were exposed to 1 microM of cisplatin for 72 hr. The level of lipid peroxides increased in the cells after 48 hr of exposure to cisplatin; the increase was more rapid than the enzyme leakage. This culture system can be used to evaluate drug-induced nephrotoxicity and its mechanism.

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