Effects of diltiazem on plasma uric acid level and renal uric acid excretion in rats. | Zendy

Haruko Sugino | Zendy; Hideyo Shimada | Zendy

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Effects of diltiazem on plasma uric acid level and renal uric acid excretion in rats.

Author(s) -

Haruko Sugino,

Hideyo Shimada

Publication year - 1989

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.50.239

Subject(s) - uric acid , diltiazem , excretion , endocrinology , medicine , chemistry , hypouricemia , renal physiology , renal blood flow , metabolism , kidney , calcium

The effects of diltiazem on plasma uric acid level (PUA) and renal uric acid excretion were investigated in oxonate-loaded rats. Diltiazem (0.5 mg/kg, i.v.) decreased PUA without producing uricosuria, and it decreased fractional excretion of uric acid and renal blood flow. The present results suggest that diltiazem produces hypouricemia not accompanied by uricosuria, probably by affecting uric acid metabolism, and it may also cause an alteration in the renal handling of uric acid partly due to changes in renal hemodynamics.

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