Open AccessEffects of diltiazem on plasma uric acid level and renal uric acid excretion in rats.
Author(s) -
Haruko Sugino,
Hideaki Shimada
Publication year - 1989
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.50.239
Subject(s) - uric acid , diltiazem , excretion , endocrinology , medicine , chemistry , hypouricemia , renal physiology , renal blood flow , metabolism , kidney , calcium
The effects of diltiazem on plasma uric acid level (PUA) and renal uric acid excretion were investigated in oxonate-loaded rats. Diltiazem (0.5 mg/kg, i.v.) decreased PUA without producing uricosuria, and it decreased fractional excretion of uric acid and renal blood flow. The present results suggest that diltiazem produces hypouricemia not accompanied by uricosuria, probably by affecting uric acid metabolism, and it may also cause an alteration in the renal handling of uric acid partly due to changes in renal hemodynamics.