Effect of diethylnitrosamine on monoamine oxidase in rat liver. | Zendy

Toshio Obata | Zendy; Hiroto Yamashita | Zendy; Toru Egashira | Zendy; Yasumitsu Yamanaka | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effect of diethylnitrosamine on monoamine oxidase in rat liver.

Author(s) -

Toshio Obata,

Hiroto Yamashita,

Toru Egashira,

Yasumitsu Yamanaka

Publication year - 1989

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.49.151

Subject(s) - monoamine oxidase , chemistry , carcinogen , monoamine oxidase a , monoamine oxidase b , enzyme , biochemistry , 2 acetylaminofluorene , pharmacology , biology , microsome

The effect of diethylnitrosamine (DEN), a well-known experimental carcinogen, toward MAO-A and MAO-B activity of rat liver was investigated. The oxidations of both beta-PEA (MAO-B) and 5-HT (MAO-A) were inhibited by DEN. The K1 values of DEN in the inhibition of rat liver MAO-A and MAO-B activity were determined. The kinetic data show that DEN is a competitive, MAO-B selective inhibitor and its inhibitory effect on MAO-B is about 4-fold more potent than that on MAO-A. DEN might change the proportions of the multiple forms of MAO activity in tumor cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research