Open AccessFacilitating Effect of Oxiracetam and Piracetam on Acquisition of Discrete Two-Way Shuttle Avoidance in Normal Mice
Author(s) -
Hisashi Kuribara,
Sakutaro Tadokoro
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.48.494
Subject(s) - piracetam , pharmacology , avoidance behaviour , anesthesia , chemistry , psychology , medicine , developmental psychology
Effects of oxiracetam and piracetam on acquisition of the discrete two-way shuttle avoidance response were investigated in normal mice of the dd strain. When oxiracetam or piracetam was administered only once immediately before the training session, the mice showed a greater number of avoidance responses in comparison with the saline-treated control mice, with the maximum effect at 30 mg/kg of oxiracetam and 100 mg/kg of piracetam. These results suggest that oxiracetam and piracetam facilitate the avoidance acquisition in normal mice.