Open AccessThe Involvement of Serotonergic and Dopaminergic Systems in Hypothermia Induced in Mice by Intracerebroventricular Injection of Serotonin
Author(s) -
Jun Yamada,
Yukihiko Sugimoto,
Hiromi Wakita,
Kazuyoshi Horisaka
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.48.145
Subject(s) - ketanserin , methysergide , hypothermia , pimozide , serotonergic , serotonin , haloperidol , dopaminergic , pindolol , thermoregulation , 5 ht receptor , pharmacology , endocrinology , medicine , chemistry , receptor , dopamine
The hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT1 receptor. In addition, haloperidol, pimozide and alpha-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.