The Involvement of Serotonergic and Dopaminergic Systems in Hypothermia Induced in Mice by Intracerebroventricular Injection of Serotonin | Zendy

Jun Yamada | Zendy; Yumi Sugimoto | Zendy; Hiromi Wakita | Zendy; Kazuyoshi Horisaka | Zendy

Open Access

The Involvement of Serotonergic and Dopaminergic Systems in Hypothermia Induced in Mice by Intracerebroventricular Injection of Serotonin

Author(s) -

Jun Yamada,

Yumi Sugimoto,

Hiromi Wakita,

Kazuyoshi Horisaka

Publication year - 1988

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.48.145

Subject(s) - ketanserin , methysergide , hypothermia , pimozide , serotonergic , serotonin , haloperidol , dopaminergic , pindolol , thermoregulation , 5 ht receptor , pharmacology , endocrinology , medicine , chemistry , receptor , dopamine

The hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT1 receptor. In addition, haloperidol, pimozide and alpha-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.

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