Open AccessChanges in Amine Oxidase in Plasma of Rats Treated with Hepatotoxins
Author(s) -
Toshio Obata,
Toru Egashira,
Yasumitsu Yamanaka
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.48.142
Subject(s) - clorgyline , carbon tetrachloride , ccl4 , chemistry , amine oxidase , amine gas treating , substrate (aquarium) , hepatotoxin , monoamine oxidase , biochemistry , enzyme , toxicity , organic chemistry , biology , ecology
When allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with beta-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl4), A-form MAO activity elevated predominantly. The deaminations of 5-HT and beta-PEA in these plasma treated with AF or CCl4 were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate that there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl4 or AF.