Open AccessProstaglandin F2.ALPHA.-induced contraction in isolated dog cerabral, coronary and mesenteric arteries soaked in excess potassium.
Author(s) -
Noboru Toda,
Hisashi Onoue
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.47.204
Subject(s) - coronary arteries , contraction (grammar) , mesenteric arteries , cerebral arteries , prostaglandin , depolarization , medicine , chemistry , endocrinology , potassium , alpha (finance) , anatomy , artery , cardiology , surgery , construct validity , organic chemistry , patient satisfaction
Concentration-response curve for prostaglandin (PG) F2 alpha in helical strips of dog cerebral, coronary and mesenteric arteries were compared in control media and in those in which all the NaCl was replaced with isomolar KCl. Contractile responses to PGF2 alpha in concentrations up to 2 x 10(-6) M in cerebral arteries, to 10(-5) M in coronary arteries and to 5 x 10(-7) M in mesenteric arteries were not attenuated by excess K+. Contractions caused by PGF2 alpha, at least at these concentrations or lower, may not be associated with membrane depolarization.