Open AccessAlloxan-diabetic state-induced suppression of Ca2+-dependent slow action potentials in mouse diaphragm muscle.
Author(s) -
Ikuko Kimura,
Tomoko Nakamura,
Masayasu Kimura
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.47.197
Subject(s) - alloxan , diaphragm (acoustics) , medicine , endocrinology , chemistry , biophysics , diabetes mellitus , biology , physics , acoustics , loudspeaker
Ca2+-dependent slow action potentials (AP) were investigated in diaphragm muscles of alloxan-diabetic mice in comparison with normal muscles. Slow APs observed in diabetic muscles were significantly decreased in amplitude and duration. The slow APs which were generated at a stimulation frequency of once every 15 sec decayed more rapidly in diabetic muscles. Fatigue, however, developed regardless of the presence of verapamil (10 microM) in contrast to the quicker development of fatigue in normal muscles in response to verapamil.