Dissolution of antisecretory and cytoprotective action of PGE2 in rats. | Zendy

Jian Ying WANG | Zendy; Koji Takeuchi | Zendy; S. Okabe | Zendy

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Dissolution of antisecretory and cytoprotective action of PGE2 in rats.

Author(s) -

Jian Ying WANG,

Koji Takeuchi,

S. Okabe

Publication year - 1988

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.47.103

Subject(s) - ethanol , pylorus , chemistry , lesion , medicine , pharmacology , oral administration , endocrinology , secretion , stomach , biochemistry , surgery

Oral administration of 60% ethanol in 150 mM HCl (HCl.ethanol) to rats produced gastric mucosal lesions within 1 hr. PGE2 given s.c. at 0.1 to 3 mg/kg 0.5 hr before HCl.ethanol significantly prevented the lesion formation. The protection afforded with 3 mg/kg of PGE2 persisted for 6 or 12 hr after administration. PGE2 given s.c. at 3 mg/kg significantly inhibited gastric secretion in pylorus-ligated and intact rats, but the action disappeared 6 hr later.

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