Open AccessDissolution of antisecretory and cytoprotective action of PGE2 in rats.
Author(s) -
Jian Ying Wang,
Koji Takeuchi,
Susumu Okabe
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.47.103
Subject(s) - ethanol , pylorus , chemistry , lesion , medicine , pharmacology , oral administration , endocrinology , secretion , stomach , biochemistry , surgery
Oral administration of 60% ethanol in 150 mM HCl (HCl.ethanol) to rats produced gastric mucosal lesions within 1 hr. PGE2 given s.c. at 0.1 to 3 mg/kg 0.5 hr before HCl.ethanol significantly prevented the lesion formation. The protection afforded with 3 mg/kg of PGE2 persisted for 6 or 12 hr after administration. PGE2 given s.c. at 3 mg/kg significantly inhibited gastric secretion in pylorus-ligated and intact rats, but the action disappeared 6 hr later.