Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice. | Zendy

Ikuko Kimura | Zendy; Tetsuo MATSUI | Zendy; Masayasu Kimura | Zendy

Open Access

Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.

Author(s) -

Ikuko Kimura,

Tetsuo MATSUI,

Masayasu Kimura

Publication year - 1988

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.46.93

Subject(s) - streptozotocin , alloxan , basal (medicine) , medicine , endocrinology , diabetes mellitus , blood pressure , pulse rate , pulse pressure , pulse (music) , engineering , detector , electrical engineering

Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CAy mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CAy) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CAy mice were significantly different from the PR one in alloxan-mice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research