Open AccessDifferent antagonistic effects of bunazosin and ketanserin on the norepinephrine-induced vasoconstriction in isolated, perfused canine and simian skeletal muscle arteries.
Author(s) -
Osman Sinanović,
Shigetoshi Chiba
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.46.200
Subject(s) - ketanserin , vasoconstriction , norepinephrine , perfusion , medicine , carnivora , vascular smooth muscle , skeletal muscle , fissipedia , endocrinology , biology , smooth muscle , serotonin , receptor , 5 ht receptor , dopamine
Blocking activities of bunazosin and ketanserin on norepinephrine (NE)-induced vasoconstrictions were investigated in isolated, perfused canine and simian skeletal muscle arteries. NE caused an increase in perfusion pressure in a dose-related manner to almost the same extent in both canine and simian arterial preparations. Bunazosin and ketanserin inhibited NE-induced vasoconstrictions much more readily in simian arteries than in canine arteries. The mechanisms for the different adrenolytic activities of alpha 1-antagonists between these two arteries were discussed.