Open AccessInhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.
Author(s) -
Nobuya Inagaki,
Tetsuji Miura,
Hiroichi Nagai,
Akihide Koda
Publication year - 1988
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.46.189
Subject(s) - histamine , dexamethasone , vascular permeability , anaphylaxis , inhibitory postsynaptic potential , chemistry , prednisolone , pharmacology , immunoglobulin e , glucocorticoid , mediator , endocrinology , medicine , allergy , immunology , antibody
Effects of hydrocortisone, prednisolone and dexamethasone on IgE antibody-mediated homologous passive cutaneous anaphylaxis (PCA) and mediator-induced skin reactions were investigated. PCA and skin reactions were evoked at the same time in the dorsal skin of a rat. Administrations of glucocorticoids inhibited not only the PCA but also the skin reactions caused by histamine, serotonin and leukotriene (LT) C4 significantly. It is suggested, therefore, that glucocorticoids inhibit the increase of vascular permeability non-specifically. This action of glucocorticoids might contribute at least in part to its inhibitory effect on the PCA.