Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats. | Zendy

Naoki Inagaki | Zendy; Toru Miura | Zendy; Hiroichi Nagai | Zendy; Akihide Koda | Zendy

Open Access

Inhibitory effects of glucocorticoids on increased vascular permeability caused by passive cutaneous anaphylaxis and some chemical mediators in rats.

Author(s) -

Naoki Inagaki,

Toru Miura,

Hiroichi Nagai,

Akihide Koda

Publication year - 1988

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.46.189

Subject(s) - histamine , dexamethasone , vascular permeability , anaphylaxis , inhibitory postsynaptic potential , chemistry , prednisolone , pharmacology , immunoglobulin e , glucocorticoid , mediator , endocrinology , medicine , allergy , immunology , antibody

Effects of hydrocortisone, prednisolone and dexamethasone on IgE antibody-mediated homologous passive cutaneous anaphylaxis (PCA) and mediator-induced skin reactions were investigated. PCA and skin reactions were evoked at the same time in the dorsal skin of a rat. Administrations of glucocorticoids inhibited not only the PCA but also the skin reactions caused by histamine, serotonin and leukotriene (LT) C4 significantly. It is suggested, therefore, that glucocorticoids inhibit the increase of vascular permeability non-specifically. This action of glucocorticoids might contribute at least in part to its inhibitory effect on the PCA.

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