Open AccessCentral dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.
Author(s) -
Francesco Squadrito,
Gioacchino Calapai,
Aldo Autolitano,
N Frisina,
Giuseppe Santoro,
Michele Buemi,
G Squadrito,
Achille P. Caputi
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.45.567
Subject(s) - medicine , endocrinology , chemistry , angiotensin ii , alpha (finance) , atrial natriuretic peptide , biology , receptor , construct validity , nursing , patient satisfaction
The effect of intracerebroventricular (i.c.v.) injection of synthetic rat atrial natriuretic polypeptide (alpha-rANP) on drinking behavior was studied in normotensive rats, alpha-rANP (0.2, 0.4 or 0.8 micrograms in 5 microliter) caused a dose-dependent dipsogenic effect which was abated by i.c.v. pretreatment with saralasine (9 micrograms in 5 microliter). These results suggest that alpha-rANP possesses dipsogenic effects in water repleted rats and that brain angiotensin is involved. In addition, our data indicate that, at least as far as the effect of cerebral ANP is concerned, there are some differences between alpha-rANP and human atrial natriuretic polypeptide.