Open AccessEffects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.
Author(s) -
Masanobu Nakahiro,
Nobuo Nishi,
Isao Fukuchi,
Daisuke Mochizuki,
Susumu Kato,
Atsushi Mizushima,
Shuji Uchida,
Hiroshi Yoshida
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.45.292
Subject(s) - gabab receptor , gabaa receptor , baclofen , receptor , gamma aminobutyric acid , chemistry , gaba receptor , gaba receptor antagonist , neuroscience , pharmacology , biology , bicuculline , biochemistry , agonist
The interactions of the "antidementia drug" pantoyl-gamma-aminobutyric acid (pantoyl-GABA) with gamma-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [3H]GABA to GABAA receptors and those of [3H]baclofen and [3H]GABA to GABAB receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA-receptors in the rat brain.