Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain. | Zendy

Masanobu Nakahiro | Zendy; Nobuo Nishi | Zendy; Isao Fukuchi | Zendy; Daisuke Mochizuki | Zendy; Susumu Kato | Zendy; Atsushi Mizushima | Zendy; Shuji Uchida | Zendy; Hiroshi Yoshida | Zendy

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Effects of pantoyl-GABA on GABAA and GABAB receptors in the rat brain.

Author(s) -

Masanobu Nakahiro,

Nobuo Nishi,

Isao Fukuchi,

Daisuke Mochizuki,

Susumu Kato,

Atsushi Mizushima,

Shuji Uchida,

Hiroshi Yoshida

Publication year - 1987

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.45.292

Subject(s) - gabab receptor , gabaa receptor , baclofen , receptor , gamma aminobutyric acid , chemistry , gaba receptor , gaba receptor antagonist , neuroscience , pharmacology , biology , bicuculline , biochemistry , agonist

The interactions of the "antidementia drug" pantoyl-gamma-aminobutyric acid (pantoyl-GABA) with gamma-aminobutyric acid (GABA) receptors were investigated by studies on bindings of radiolabelled ligands in rat brain. Pantoyl-GABA inhibited the binding of [3H]GABA to GABAA receptors and those of [3H]baclofen and [3H]GABA to GABAB receptors in the rat cerebral cortex. These data suggest that pantoyl-GABA interacts with both types of GABA-receptors in the rat brain.

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