Open AccessEffects of antibiotics on fibrinolytic activity in vivo.
Author(s) -
Isamu Okuno,
Keiji Uchida
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.44.215
Subject(s) - latamoxef , cefamandole , antibiotics , in vivo , carbenicillin , fibrinolysis , cefotaxime , moxalactam , pharmacology , chemistry , hypoprothrombinemia , lysis , in vitro , medicine , microbiology and biotechnology , biochemistry , biology , cephalosporin , vitamin k , gentamicin
The effects of latamoxef, cefamandole, carbenicillin and cefotaxime on fibrinolytic system in rats were examined under feeding of an ordinary diet or a vitamin K-deficient diet for eight days. No obvious change was observed in UK-induced plasma clot lysis time, euglobulin lysis time and antiplasmin level in plasma. These findings of the in vitro and ex vivo studies suggest that these antibiotics cause no enhancement of fibrinolytic activity.