Effects of antibiotics on fibrinolytic activity in vivo. | Zendy

Isamu Okuno | Zendy; Kiyohisa Uchida | Zendy

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Effects of antibiotics on fibrinolytic activity in vivo.

Author(s) -

Isamu Okuno,

Kiyohisa Uchida

Publication year - 1987

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.44.215

Subject(s) - latamoxef , cefamandole , antibiotics , in vivo , carbenicillin , fibrinolysis , cefotaxime , moxalactam , pharmacology , chemistry , hypoprothrombinemia , lysis , in vitro , medicine , microbiology and biotechnology , biochemistry , biology , cephalosporin , vitamin k , gentamicin

The effects of latamoxef, cefamandole, carbenicillin and cefotaxime on fibrinolytic system in rats were examined under feeding of an ordinary diet or a vitamin K-deficient diet for eight days. No obvious change was observed in UK-induced plasma clot lysis time, euglobulin lysis time and antiplasmin level in plasma. These findings of the in vitro and ex vivo studies suggest that these antibiotics cause no enhancement of fibrinolytic activity.

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