Open AccessAlpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig
Author(s) -
Norio Inomata,
Norio Ohnuma,
Masako Furuya,
Yujiro Hayashi,
Yasushi Kanai,
Takafumi Ishihara,
Teruhisa Noguchi,
Hisayuki Matsuo
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.44.211
Subject(s) - pulmonary edema , arachidonic acid , guinea pig , lung , atrial natriuretic peptide , receptor , edema , medicine , endocrinology , chemistry , pulmonary artery , pharmacology , biochemistry , enzyme
Protective effect of alpha-human atrial natriuretic peptide (alpha-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of alpha-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 micrograms of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of alpha-hANP was considered to be receptor mediated because the effective concentration was close to the Kd value of the binding of the ANP receptors in the lung homogenate.