Open AccessEffect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.
Author(s) -
Hiroshi Takahashi,
Manabu Shibata,
Tsuyako Ohkubo,
Kihachi Saito,
Reizo Inoki
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.43.441
Subject(s) - melatonin , hyperalgesia , licking , (+) naloxone , prostaglandin e2 , chemistry , subcutaneous injection , morphine , nociception , pharmacology , biting , endocrinology , medicine , opioid , biology , receptor , ecology
Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically. The first and second phases were enhanced by melatonin and melatonin, naloxone, prostaglandin E2, respectively. Mice kept in the dark also exhibited hyperalgesic response. When neurotropin was injected intraperitoneally 30 min prior to those treatments, hyperalgesia was suppressed to the control level. Aspirin inhibited only the second hyperalgesic phase.