Open AccessDistribution of cholinesterase in canine venous system.
Author(s) -
Tatsuji Furuta,
Akihiro Hayakawa,
Noriko Iida,
Akemi Inagaki,
Tatsuro Shigei
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.43.237
Subject(s) - neostigmine , cholinesterase , acetylcholine , long term potentiation , inferior vena cava , anatomy , contractility , smooth muscle , chemistry , medicine , endocrinology , biology , receptor
Cholinesterase (ChE) activity was examined in 15 veins from dogs by pharmacological and histochemical procedures. Potentiation of acetylcholine (ACh)-induced contractile response by neostigmine was observed in helical and longitudinal strips of portal, mesenteric veins and middle segment of the inferior vena cava, but not in the other 12 veins. Histochemical studies with an electron-microscope (the method of Karnovsky-Roots) revealed that ChE activity was identified as high density granules around the smooth muscle cells only in the former three veins. The visible ChE activity was abolished by pretreatment with neostigmine.