Effect of concanavalin A on 5'-nucleotidase activity of rabbit blood platelets. | Zendy

Hiroaki Nishio | Zendy; Keiko Takeshita | Zendy; Kimiko OKUGAWA | Zendy; Tomio Segawa | Zendy

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Effect of concanavalin A on 5'-nucleotidase activity of rabbit blood platelets.

Author(s) -

Hiroaki Nishio,

Keiko Takeshita,

Kimiko OKUGAWA,

Tomio Segawa

Publication year - 1987

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.43.230

Subject(s) - concanavalin a , platelet , 5' nucleotidase , adenosine , adenosine deaminase , nucleotidase , antagonist , chemistry , medicine , biochemistry , endocrinology , microbiology and biotechnology , biology , receptor , in vitro

Ecto-5'-nucleotidase (ecto-5'-NU) of platelets was enhanced by concanavalin A (Con A). This effect of Con A was antagonized by alpha-methyl-D-mannose, a specific antagonist of Con A binding to glycoprotein. Coformycin, an adenosine deaminase inhibitor, did not change the effect of Con A on the ecto-5'-NU. Uptake of adenosine by platelets was not affected by Con A. It was suggested that the ecto-5'-NU of platelet might be a direct and primary site of action of Con A.

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