Open AccessEffects of quinidine and cimetidine on the methamphetamine level in the rat brain.
Author(s) -
Tsutomu Suzuki,
Horng-Jen Fan Chiang,
Miwa Misawa
Publication year - 1987
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.43.103
Subject(s) - methamphetamine , cimetidine , quinidine , amphetamine , pharmacology , metabolite , chemistry , drug , medicine , dopamine , biochemistry
The drug interaction between methamphetamine and quinidine/cimetidine was investigated in terms of distribution of methamphetamine to the brain. The concentrations of methamphetamine and amphetamine in the brain after an s.c. injection of methamphetamine were determined in rats pretreated with a single oral dose of quinidine or cimetidine. Both drugs markedly enhanced the increase in the concentrations of methamphetamine and its metabolite, amphetamine. These results suggest that the recent finding of the enhancements of the behavioral effect of methamphetamine by quinidine and cimetidine is due to the increase in levels of methamphetamine and amphetamine in the brain by these pretreatment drugs.