Open AccessEffects of a New Anti-Inflammatory Imidazole Derivative, Fenflumizole, on Platelet Aggregation in the Rabbit
Author(s) -
Junichiro Aono,
Hiroyuki Nabata,
Kazushige Sakai
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.42.575
Subject(s) - ticlopidine , aspirin , ex vivo , chemistry , in vivo , pharmacology , platelet , in vitro , platelet aggregation , platelet aggregation inhibitor , biochemistry , medicine , biology , clopidogrel , microbiology and biotechnology
The antiplatelet effect of fenflumizole, compared with aspirin or ticlopidine, was examined in in vitro, ex vivo and in vivo situations of the rabbit. Unlike ticlopidine, fenflumizole and aspirin effectively inhibited in vitro the platelet aggregation elicited by arachidonate and collagen. The activity of fenflumizole was 350 times more potent than that of aspirin. Fenflumizole (0.3-3 mg/kg) given p.o. was 4.2 and 8.1 times more potent than aspirin in inhibiting arachidonate- and collagen-induced platelet aggregations, respectively. Ticlopidine (300 mg/kg, p.o.) resulted in only weak effects on the aggregations. Fenflumizole (3 mg/kg) as well as aspirin (10 mg/kg) given p.o., unlike ticlopidine (300 mg/kg), effectively prevented the arachidonate-induced sudden death.