Open AccessInhibitory Effect of Human Urinary Trypsin Inhibitor (Urinastatin) on Lysosomal Thiol Proteinases
Author(s) -
Tadahiro Shikimi,
Masanori Handa
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.42.571
Subject(s) - trypsin , cathepsin , cathepsin b , thiol , chemistry , acute pancreatitis , pancreatitis , in vitro , enzyme inhibitor , inhibitory postsynaptic potential , urinary system , biochemistry , enzyme , pharmacology , medicine
Effects of human urinary trypsin inhibitor, urinastatin, a compound clinically prescribed for treatment of acute pancreatitis, on lysosomal thiol proteinases were studied. Urinastatin had inhibitory effect on the activities of cathepsins B and H in vitro. In the experimental acute pancreatitis induced by a closed duodenal loop, urinastatin prevented the enhancement of esterolytic activity and the activities of cathepsins B and H. Urinastatin also improved the activities of inhibitors of cathepsins B and H in the case of pancreatitis.