Inhibitory Effect of Human Urinary Trypsin Inhibitor (Urinastatin) on Lysosomal Thiol Proteinases | Zendy

Tadahiro Shikimi | Zendy; Masanori Handa | Zendy

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Inhibitory Effect of Human Urinary Trypsin Inhibitor (Urinastatin) on Lysosomal Thiol Proteinases

Author(s) -

Tadahiro Shikimi,

Masanori Handa

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.42.571

Subject(s) - trypsin , cathepsin , cathepsin b , thiol , chemistry , acute pancreatitis , pancreatitis , in vitro , enzyme inhibitor , inhibitory postsynaptic potential , urinary system , biochemistry , enzyme , pharmacology , medicine

Effects of human urinary trypsin inhibitor, urinastatin, a compound clinically prescribed for treatment of acute pancreatitis, on lysosomal thiol proteinases were studied. Urinastatin had inhibitory effect on the activities of cathepsins B and H in vitro. In the experimental acute pancreatitis induced by a closed duodenal loop, urinastatin prevented the enhancement of esterolytic activity and the activities of cathepsins B and H. Urinastatin also improved the activities of inhibitors of cathepsins B and H in the case of pancreatitis.

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