Open AccessTaurine Transport in Chronically Stimulated Fast- and Slow-Twitch Muscles of the Rat
Author(s) -
Bong Ki Kim,
Akemichi Baba,
Hisato Iwata
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.42.441
Subject(s) - taurine , stimulation , medicine , endocrinology , fast twitch muscle , extensor digitorum longus muscle , sciatic nerve , soleus muscle , chemistry , hindlimb , stimulus (psychology) , skeletal muscle , anatomy , biology , biochemistry , amino acid , psychology , psychotherapist
Indirect stimulation via the sciatic nerve, 10 or 100 Hz stimulus trains of 1 sec duration, applied every 3 sec, 8 hr/day for 1-4 weeks increased taurine concentration of the extensor digitorum longus (EDL, fast-twitch) muscle of the rat. The uptake of [3H]-taurine into the EDL and tibialis anterior (TA, fast-twitch) muscle was also increased by the stimulation. Concentration and uptake of taurine in the soleus muscle (SL, slow-twitch) did not change by chronic 10 Hz stimulation. Taurine concentration in the SL muscle was significantly reduced by chronic 100 Hz stimulation. This study shows that chronic nerve stimulation increases the uptake of taurine in the fast-twitch muscles, but not in the slow-twitch muscle.