Open AccessEffects of Antibiotics on Fibrinolytic Activity
Author(s) -
Isamu Okuno,
Yumi Fujiharu,
Keiji Uchida
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.42.150
Subject(s) - latamoxef , cefamandole , antifibrinolytic , fibrin , fibrinolysis , carbenicillin , cefotaxime , antibiotics , lysis , chemistry , pharmacology , moxalactam , sisomicin , streptokinase , in vitro , microbiology and biotechnology , biochemistry , medicine , immunology , cephalosporin , biology , tranexamic acid , surgery , gentamicin , blood loss , tobramycin , myocardial infarction
Latamoxef, cefamandole, carbenicillin and cefotaxime were examined for their effects on fibrinolytic activity in vitro by means of the fibrin plate method, fibrin clot lysis time and euglobulin lysis time with human, rabbit and rat plasma. These antibiotics showed no fibrinolytic but weak antifibrinolytic activity at 1000 or 3000 micrograms/ml in some assay systems.