Effects of Antibiotics on Fibrinolytic Activity | Zendy

Isamu Okuno | Zendy; Yumi FUJIHARU | Zendy; Kiyohisa Uchida | Zendy

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Effects of Antibiotics on Fibrinolytic Activity

Author(s) -

Isamu Okuno,

Yumi FUJIHARU,

Kiyohisa Uchida

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.42.150

Subject(s) - latamoxef , cefamandole , antifibrinolytic , fibrin , fibrinolysis , carbenicillin , cefotaxime , antibiotics , lysis , chemistry , pharmacology , moxalactam , sisomicin , streptokinase , in vitro , microbiology and biotechnology , biochemistry , medicine , immunology , cephalosporin , biology , tranexamic acid , surgery , gentamicin , blood loss , tobramycin , myocardial infarction

Latamoxef, cefamandole, carbenicillin and cefotaxime were examined for their effects on fibrinolytic activity in vitro by means of the fibrin plate method, fibrin clot lysis time and euglobulin lysis time with human, rabbit and rat plasma. These antibiotics showed no fibrinolytic but weak antifibrinolytic activity at 1000 or 3000 micrograms/ml in some assay systems.

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