Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain | Zendy

Masahiro Nishibori | Zendy; Ryozo Oishi | Zendy; Yoshinori Itoh | Zendy; Kiyomi Saeki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Author(s) -

Masahiro Nishibori,

Ryozo Oishi,

Yoshinori Itoh,

Kiyomi Saeki

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.41.403

Subject(s) - histaminergic , muscimol , pargyline , aminooxyacetic acid , chemistry , histamine , baclofen , glutamate decarboxylase , pharmacology , endocrinology , histidine decarboxylase , medicine , gabaa receptor , agonist , biochemistry , histidine , biology , amino acid , monoamine oxidase , receptor , enzyme

The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research