Open AccessEffects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain
Author(s) -
Masahiro Nishibori,
Ryozo Oishi,
Yoshinori Itoh,
Kiyomi Saeki
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.41.403
Subject(s) - histaminergic , muscimol , pargyline , aminooxyacetic acid , chemistry , histamine , baclofen , glutamate decarboxylase , pharmacology , endocrinology , histidine decarboxylase , medicine , gabaa receptor , agonist , biochemistry , histidine , biology , amino acid , monoamine oxidase , receptor , enzyme
The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.