Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats | Zendy

S. N. Dube | Zendy; Abhik Ghosh | Zendy; K Jeevarathinam | Zendy; D. Kishore Kumar | Zendy; Smita Gupta | Zendy; B. P. Pant | Zendy; B. S. BATRA | Zendy; D. K. Jaiswal | Zendy

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Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats

Author(s) -

S. N. Dube,

Abhik Ghosh,

K Jeevarathinam,

D. Kishore Kumar,

Smita Gupta,

B. P. Pant,

B. S. BATRA,

D. K. Jaiswal

Publication year - 1986

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.41.267

Subject(s) - antidote , cholinesterase , pharmacology , atropine , toxicology , dichlorvos , chemistry , sarin , medicine , fire retardant , anesthesia , toxicity , acetylcholinesterase , biochemistry , biology , enzyme , organic chemistry , pesticide , agronomy

Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.

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