Open AccessStudies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats
Author(s) -
S. N. Dube,
A. K. Ghosh,
K. Jeevarathinam,
Dinesh Kumar,
Sumanta Gupta,
B. P. Pant,
B. S. Batra,
Devendra K. Jaiswal
Publication year - 1986
Publication title -
japanese journal of pharmacology/japanese journal of pharmacology
Language(s) - English
Resource type - Journals
eISSN - 1347-3506
pISSN - 0021-5198
DOI - 10.1254/jjp.41.267
Subject(s) - antidote , cholinesterase , pharmacology , atropine , dichlorvos , toxicology , chemistry , anesthesia , medicine , toxicity , biology , pesticide , organic chemistry , agronomy
Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.